29.6 P A greater percentage of linaclotide patients vs. Placebo patients were also responders for the other three primary end points (P Significantly greater improvements were seen in linaclotide vs. Placebo patients for all secondary end points (P During the RW period, patients remaining on linaclotide showed sustained improvement; patients re randomized from linaclotide to placebo showed return of symptoms, but without worsening of symptoms relative to baseline.
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